10 Best Weight Loss Pills & Diet Supplements to Lose Weight Fast

Instant Knockout is an effective weight loss pill that was originally created for MMA fighters and professional boxers to cut excess pounds before a big fight. Instant Knockout is now available to the general public for anyone that wants to get a shredded physique.

How Does Instant Knockout Work?

The manufacturers of Instant Knockout collaborated with legendary MMA coach Greg Jackson to develop this premium fat-burning system that will help you lose weight and build lean muscle mass. The Instant Knockout system emphasizes the four cornerstones of weight loss:

1. Calorie control
2. Appetite control
3. Thermogenic boost
4. Well-balanced diet

How does Instant Knockout work to help you achieve rapid fat loss? Instant Knockout triggers thermogenesis to help you eliminate stubborn belly fat and build muscle mass at the same time. Here are the advertised benefits of taking this effective weight loss pill:

1. Increased Metabolism

Instant Knockout increases your body’s metabolic rate, allowing you to burn excess fat even when you’re not actively working out.

2. Sustained Energy Boost

The ingredients in Instant Knockout provide your body with a sustained boost of clean energy all day long, even during high-intensity workouts.

3. Curbs Hunger Cravings

Instant Knockout uses one of the most effective ingredients for weight loss pills that double as appetite suppressants: glucomannan. The dietary fiber expands in your stomach, keeping you full between meals and eliminating midday hunger cravings.

Formula and Ingredients

If you have some lofty health and fitness goals, then Instant Knockout is the weight loss pill to help you achieve them. It’s one of the best diet pills to boost metabolism and help your body burn excess fat without losing any muscle mass. Here are the ingredients you’ll find in Instant Knockout Cut:

• Cayenne pepper
• Vitamin D3, B6, B12
• Green tea extract
• Glucomannan
• L-theanine
• Caffeine
• Black pepper extract
• Vegetable cellulose (capsule)
• Magnesium stearate (bonding agent)

Key Features

Instant Knockout is one of the best diet pills to help you kickstart your metabolism and incinerate stubborn belly fat. It’s been in continuous development for over ten years, making it one of the most effective diet supplements and appetite suppressants on today’s market.

• Vegan-friendly product
• Complete fat burning system
• 100% safe and natural ingredients
• 24-hour appetite suppressant
• Bulk buy discounts for multiple bottles
• Free shipping available

Who Is This Product Best for?

Instant Knockout is the best fat burner for men that want to lose weight while keeping muscle. This powerful weight loss pill revs up your body’s metabolism so that you can burn fat 24 hours a day, even while sleeping. Instant Knockout is a great option for athletes, professional fighters, and gym goers.

Click Here for the Lowest Price on Instant Knockout

How We Ranked the Best Diet Pills for Weight Loss

The diet pill industry in the U.S. is booming. With such a large selection to choose from, finding the right type of weight loss pill to suit your needs can seem overwhelming. This review used numerous ranking factors to ensure that we chose the best weight loss pills that would be safe, effective, and contain natural ingredients.

Formula and Dosage

Two of the most critical ranking factors we looked at were formula and dosages. The most effective weight loss pills include clinically proven ingredients, with research and studies backing up their fat-burning and weight loss properties.

Finding the correct dosage is essential for two obvious reasons. First, taking a diet pill without enough of the most effective ingredients may not provide you with the results you want. Second, taking a diet pill with a dosage over the maximum may cause side effects, especially if it contains caffeine.

People with sensitivities to stimulants may find themselves with a case of the jitters or high blood pressure spikes. As you can see, formula and dosages are extremely important when choosing weight loss supplements.

Safety

When we researched the best weight loss pills, we also looked at the safety of each formula. In the world of diet pills, there have been numerous ingredients banned by the FDA as being hazardous to your health:

• Sibutramine
• Synephrine (bitter orange)
• Ephedra (ma huang)
• DMAA
• Fenproporex
• Fen-Phen (fenfluramine/phentermine)
• Phenolphthalein
• Clenbuterol (Clen Fat Burner)

None of the weight loss pills in this review contained any harmful or banned substances. The ingredients in these five supplements will not cause adverse side effects as long as you use them correctly and follow the dosage recommendations.

Reviews

Customer reviews were another crucial ranking factor we used while researching the five best weight loss supplements in 2022. Reading reviews from real-life customers provides excellent insight into the product’s effectiveness and whether it works the way its manufacturers claim.

Don’t just look on the website for reviews, either. If you’re researching fat-burning supplements, check sites like Google, the Better Business Bureau, and popular e-commerce platforms. If you find an overwhelming number of unhappy customers, you may want to purchase a different type of weight loss pill.

Price per Serving

The best weight loss supplements can be expensive, but remember: The results are worth it. However, that doesn’t mean that you can’t find ways to save money on your order. For example, all of the diet pills in this review offered bulk-buy discounts for multiple bottles. Some websites also featured limited-time discount codes, allowing you to take advantage of promos like free shipping or 10% off.

Understanding the Different Types of Weight Loss Pills

The best weight pills target specific metabolic pathways to help you lose weight. Knowing how various popular weight loss pills work makes it easier to choose one that addresses your weight loss challenge. For instance, if you suffer from cravings that derail your diet, an appetite suppressant that helps you feel full may be a better diet pill than a fat burner.

Many of the best weight loss pills on the market use a combination of ingredients that simultaneously target several aspects of weight loss. These multi-purpose fat-burning supplements are great for general weight loss, but if you have a particular problem area, such as wanting to lose belly fat, choosing a specific diet loss pill may be the smarter choice.

Fat Burners (Thermogenics)

Fat burners are one of the best supplements on the market for weight loss. Thermogenesis is a vital part of maintaining your body’s core temperature and contributes to your body’s basal metabolic rate (BMR), which is the number of calories you need per day simply to stay alive. If you don’t get enough calories from your diet, your body will burn stored fat for energy instead.

Increasing thermogenesis forces your body to maintain a slightly elevated basal metabolic rate. Since dieting relies on eating fewer calories than you burn, increasing how many calories your body needs will force your body to start burning fat and help you shed any excess weight.

While a thermogenic fat burner can promote weight loss and eliminate stubborn body fat, this category has the most side effects. Most thermogenic compounds that boost metabolism are stimulants and result in an elevated heart rate and improved energy. In some individuals, stimulants can also produce an unpleasant jittery effect, nausea, and insomnia.

Even if you tolerate stimulants such as caffeine, check the label on your preferred natural fat burner. Some will take a thermogenic fat burner that combines multiple ingredients that contain caffeine, such as green tea extract and green coffee bean extract, which greatly increases the amount of caffeine you consume. If you start experiencing negative side effects from a thermogenic fat burner, consider moving to weight loss capsules that focus on controlling food cravings, such as Leanbean, instead.

Appetite Suppressants (Anorectics)

Appetite suppressants help you lose body weight by reducing food cravings and controlling appetite, resulting in calorie restriction. Many people find sticking to a diet the toughest part of the weight-loss process. Having to spend less time fighting the urge to snack means you have more willpower to address the other aspects of losing weight, such as keeping to a healthy exercise routine.

This weight loss pill is usually the top recommended weight loss option for women, who have a harder time dealing with cravings than men.

Appetite suppression works using one of two methods: disrupting the hunger pathway to the brain or tricking your stomach into thinking it’s full. The top natural appetite suppressant, glucomannan, works by absorbing water and swelling up in the stomach, which will keep sending “full” signals to the brain, keeping you satiated for longer.

Carb Blockers

Carb blockers are dietary supplements that aim to inhibit the digestion and absorption of carbohydrates in the body. They typically contain natural ingredients such as white kidney bean extract, which inhibits the enzyme responsible for breaking down complex carbohydrates into simple sugars. By blocking this enzyme, carb blockers claim to reduce the amount of glucose absorbed from the digestive tract, potentially leading to weight loss or better blood sugar control. However, the effectiveness of carb blockers is still a subject of debate, and they should not be considered a magic solution for weight management.

Prescription Weight Loss Drugs

Most over-the-counter diet supplements use natural ingredients to gently boost your body’s normal fat-burning process, but even the best weight loss pills are usually not enough to combat severe obesity. If you’re struggling to achieve significant weight loss, your doctor may recommend prescription weight loss medication instead.

Prescription weight loss tablets are more effective at weight loss but tend to have more severe side effects than popular weight loss supplements. Doctors will only prescribe these diet aids to people with a very high body mass index (BMI) and other weight-related conditions such as Type 2 diabetes or cardiovascular disease.

While the FDA has approved several prescription drugs for long-term use, others may cause dependence and are only used for a few weeks at most.

Over-the-Counter Dietary Supplements for Weight Loss

Glucomannan

Glucomannan is a dietary fiber isolated from the konjac plant. It’s a popular appetite suppressant that absorbs water and forms a gel-like mass in your stomach. As it takes longer to pass through your digestive system, you’ll feel fuller for longer and have fewer cravings and hunger pangs.

It promotes diet adherence and reduces the average number of calories you eat daily, speeding up weight loss and making it easier to stay on track. Studies show that glucomannan is effective at promoting weight loss in overweight individuals and has the added benefit of lowering blood sugar and blood cholesterol levels while combating constipation, a common benefit of dietary fiber.

Green Tea Extract

Green tea extract contains several different ingredients that may promote fat burning, including caffeine, catechins, and antioxidants. Caffeine is a known stimulant and thermogenic compound that also assists appetite suppression, while catechins increase fat oxidation and help maintain a stable body weight after fat loss.

Several studies show that green tea extract can increase fat burning and may even be able to target belly fat. However, green tea does contain large amounts of caffeine, which may make it unsuitable for individuals who dislike the jittery feeling of excessive stimulant use, especially when the supplement has other sources of caffeine.

Chromium or Chromium Picolinate

Chromium is an essential mineral that assists insulin in its function of regulating blood sugar levels. Being an essential mineral means that your body can’t produce it, so you need to obtain it through your diet. Since your body only absorbs approximately 2.5% of the chromium you eat, a severely limited diet may lower chromium levels, resulting in poor insulin response and fatigue.

Cayenne Pepper

Cayenne pepper extract contains capsaicin, the compound responsible for the burning feeling associated with eating chilis and peppers. Capsaicin is a thermogenic compound that may aid in boosting metabolism and reducing appetite. It also enhances fat oxidation, meaning that your body can burn fat faster, supplying you with energy while helping you lose weight. Even better, the enhanced fat oxidation can help you maintain your new weight after you’ve reached your goal.

L-Carnitine

L-carnitine is an amino acid that plays a vital role in energy production in cells. Since L-carnitine plays an important role in fatty acid metabolism, research has examined how supplementation affects weight loss in humans.

While some studies show promise, other results are mixed due to poor sample selection and controls, and more rigorous research is necessary to discover how effective carnitine is at promoting fat loss.

Green Coffee Extract

Green coffee extract contains several compounds that may assist in weight loss, including caffeine and chlorogenic acid. The roasting process significantly affects chlorogenic acid levels, which is why most natural fat-burning supplements contain unroasted green coffee beans.

Several small-scale studies show that green coffee bean extract is moderately successful in improving weight loss outcomes in overweight individuals, but further research is essential in determining how effective this compound is, especially compared to simply using caffeine.

Caffeine Anhydrous

Caffeine is one of the most popular ingredients in weight loss supplements due to its established effectiveness as a metabolism booster and appetite suppressant. Caffeine can boost your basal metabolic rate by up to 11%, and some studies show that it may increase your body’s fat-burning capability by 29%.

It also acts as a stimulant and can provide the energy you need to power through tough workouts, which is especially useful if you’re dieting and have a severe calorie deficit. However, be careful of diet pills that combine ingredients such as green tea extract, green coffee bean extract, and caffeine, as these will have much more caffeine than your average cup of coffee.

Forskolin

Forskolin is a compound found in mint that may stimulate fat oxidation by raising cAMP levels in cells in rats. Current research is limited to two small-scale studies that offer conflicting results. While it shows promise, further research is necessary to determine whether it’s an effective compound that assists in human weight loss.

Conjugated Linoleic Acid

Conjugated linoleic acid is a fatty acid found in meat and dairy products that has potential weight loss benefits. It inhibits insulin signaling, preventing the body from absorbing blood sugars, reducing caloric intake, and burning excess fat. A metastudy of current research shows that CLA has a modest impact on weight loss in humans that may not be worth the adverse side effects associated with the supplement.

The same studies that showed CLA’s effect on weight loss also showed that CLA increased inflammation and raised levels of liver enzymes, indicating possible liver damage.

Anti-Obesity Medication for Weight Loss

While natural weight loss supplements offer modest weight loss benefits, they may not be up to the task of helping severely obese individuals lose weight. Doctors will only consider recommending a prescription weight loss pill if a healthy diet and exercise program fails to produce results. These weight loss pills have undergone an FDA approval process to verify their safety and efficacy and may be an option if you’re not losing weight despite maintaining a healthy lifestyle.

Orlistat

Also known as Xenical, Orlistat works by inhibiting fat absorption in the intestine, resulting in your body absorbing fewer calories from the food you eat. Studies show that Orlistat is effective at helping people lose an average of 6.4 pounds but does have side effects, including loose stools due to undigested fat in the intestine. A low-fat diet can alleviate this issue while assisting in your weight loss goals.

Doctors usually prescribe Orlistat to individuals with existing medical conditions, such as high blood pressure or diabetes, to alleviate weight-related issues.

Phentermine

Phentermine is a stimulant that acts primarily as an appetite suppressant. It is effective at helping individuals lose up to 5% of their starting body weight, but its potentially addictive nature makes it a short-term solution for moderate weight loss.

Bupropion-Naltrexone

Also known as Contrave, this combination of two drugs — bupropion and naltrexone — works by increasing thermogenesis and suppressing appetite. It’s an effective long-term solution with disturbing side effects, such as suicidal thoughts, during the starting phase.

Frequently Asked Questions About Weight Loss Pills

Is Hydroxycut good for losing weight?

Hydroxycut alone can’t promote weight loss without a healthy diet and exercise program. Some users claim to experience additional energy with Hydroxycut, which is likely due to its caffeine content. Hydroxycut can help provide energy to fuel your workouts, but it’s unlikely to reduce body mass index on its own.

Can you get phentermine pills over the counter?

No, you can’t get phentermine pills over the counter without a prescription. However, there are natural diet capsules that offer similar benefits to phentermine without the same side effects.

Phentermine is a prescription weight loss drug that requires a doctor’s prescription due to its addictive nature. If you’re still at the beginning of your weight loss journey, consider starting on natural weight loss supplements that are safer and don’t require a doctor’s prescription. Many top weight loss pills cost less than prescription bills and may be enough to promote your body’s ability to burn fat.

Are natural diet pills effective for weight management?

Yes, natural weight loss capsules can be effective for weight management and to prevent obesity. The top weight loss supplements contain ingredients that may contribute to weight reduction and make staying at a stable weight easier by preventing fat accumulation. Appetite suppressants, in particular, are excellent at weight management, as they ensure you don’t get cravings that can negatively affect your healthy eating plan.

Can weight loss supplements work without a healthy diet and exercise?

Some weight loss supplements can work without diet and exercise, such as thermogenic fat burners. These diet tablets have ingredients that ignite thermogenesis in the body to burn stubborn fat. However, all natural weight loss supplements work better when combined with a calorie-controlled diet and exercise program.

Can slimming pills reduce adipose tissue to lose weight?

While the top diet pills may not reduce the number of fat cells in your body, they can promote fat metabolism and deplete these cells faster. Some of the best natural fat burner supplements will continue to promote fat oxidation when you hit your goal weight, making it less likely that you’ll put on those lost pounds.

Can weight loss products help prevent weight gain and obesity?

While sticking to your healthy diet and exercise plan is the best way to keep weight off, natural weight loss pills can make it easier to stick to your program — some will provide you with extra energy to keep you working hard in the gym, while others will help you stick to your diet by controlling cravings. The best weight loss pills will target weight reduction in several ways to help you lose fat and keep it off.

Can the best diet pills increase my metabolism and energy?

Many of the best diet pills contain ingredients like caffeine and cayenne pepper extract, which boost energy. These ingredients raise your metabolism through increased thermogenesis and promote faster fat loss, which translates to extra energy to help you stick to your exercise and diet plan.

Who should consider prescription weight loss drugs?

Prescription weight loss drugs are suitable for people with a body mass index (BMI) over 30 and haven’t found success with natural dietary supplements for weight loss. Currently, the FDA has only approved four options for a prescription weight loss pill. Those options include:

1. Bupropion-naltrexone (Contrave)
2. Orlistat (Xenical)
3. Liraglutide (Saxenda)
4. Phentermine-topiramate (Osymia)

Studies have shown that taking prescription weight loss pills and making lifestyle changes can help you lose about 3% to 12% more body weight than if you just made lifestyle changes. However, please remember that everybody is different, and your results using a weight loss drug may vary. You may want to try over-the-counter weight loss pills first, like the ones we reviewed in this post.

Final Thoughts on Diet Pills

Whether you’re already working hard to make better lifestyle choices or have just begun your weight loss journey, adding a dietary supplement to your health and fitness regimen can provide some excellent benefits. To find the best weight loss pills, look for all-natural formulas, a money-back guarantee, and scientific studies that prove the ingredients are effective.

Each of the popular weight loss supplements in this review can help you burn fat, lose weight, and reach your fitness goals faster. Get ready to put in the work, and we promise that the confidence and results you’ll gain will be worth the effort.

Summary of the Top Recommended Weight Loss Pills

• PhenQ: Best weight loss supplement overall
• PrimeShred: Strongest weight loss pill for men
• Leanbean: Great for cravings and appetite suppression
• PhenGold: Best alternative to prescription weight loss pills
• Instant Knockout Cut: Best belly fat burner
• Trimtone: Great fat loss pill for women over 50
• PhenQ PM: Top recommended nighttime fat burner
• CalmLean: Best stimulant-free diet aid
• Burn Lab Pro: Good skinny pill for intermittent fasting
• Keto Charge: Best for keto diet

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*This article is provided by an advertiser. Statements made are not meant to offer medical advice or to diagnose any condition. Any studies cited here may be preliminary, may or may not be peer-reviewed, and may or may not have sufficient participants to be statistically relevant. Anecdotal accounts should not be taken as scientific results. Products discussed in this article are not designed to diagnose, treat, prevent, or cure any disease. The FDA does not evaluate dietary supplements. Consult your doctor about possible interactions, allergies, and if you are considering using natural and/or dietary supplements for any condition. Individual results will vary.